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Title: Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation
Authors: Novickij, Vitalij
Švedienė, Jurgita
Paškevičius, Algimantas
Markovskaja, Svetlana
Lastauskienė, Eglė
Zinkevičienė, Auksė
Girkontaitė, Irutė
Novickij, Jurij
Keywords: antibiotics
electric field
drug resistance
membrane permeabilization
S. aureus
Issue Date: 2018
Publisher: MDPI
Citation: Novickij, V.; Švedienė, J.; Paškevičius, A.; Markovskaja, S.; Lastauskienė, E.; Zinkevičienė, A.; Girkontaitė, I.; Novickij, J. Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation. Molecules 2018, 23, 1799.
Series/Report no.: 23;7
Abstract: Treatment of bacteria-associated infections is complicated and antibiotic treatment alone is often inadequate to overcome biofilm infections. Physical methods allow overcoming this problem and propose solutions that are non-dependent on drug resistance. In this work, we investigated the feasibility of pulsed electric fields for sensitization of MRSA to common antibiotics. We analyzed the efficacy of inactivation of methicillin-resistant Staphylococcus aureus in 5–20 kV/cm electric field separately and in combination with gentamicin, doxycycline, ciprofloxacin, sulfamethoxazole, and vancomycin. Combined treatment allowed using up to 1000-fold smaller concentrations of antibiotics to induce the same inactivation of S. aureus.
Description: This article belongs to the Collection Antibiotics & Superbugs: New Strategies to Combat Antimicrobial Resistance
ISSN: 1420-3049
Appears in Collections:Moksliniai straipsniai / Research articles

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