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Title: Non-Coding RNAs in Glioma
Authors: Rynkevičienė, Rytė
Šimienė, Julija
Strainienė, Eglė
Stankevičius, Vaidotas
Ušinskienė, Jurgita
Mišeikytė Kaubrienė, Edita
Meškinytė, Ingrida
Cicėnas, Jonas
Sužiedėlis, Kęstutis
Keywords: non-coding RNA
Issue Date: 2019
Publisher: MDPI
Citation: Rynkeviciene, R.; Simiene, J.; Strainiene, E.; Stankevicius, V.; Usinskiene, J.; Miseikyte Kaubriene, E.; Meskinyte, I.; Cicenas, J.; Suziedelis, K. Non-Coding RNAs in Glioma. Cancers 2019, 11, 17.
Series/Report no.: 11;1
Abstract: Glioma is the most aggressive brain tumor of the central nervous system. The ability of glioma cells to migrate, rapidly diffuse and invade normal adjacent tissue, their sustained proliferation, and heterogeneity contribute to an overall survival of approximately 15 months for most patients with high grade glioma. Numerous studies indicate that non-coding RNA species have critical functions across biological processes that regulate glioma initiation and progression. Recently, new data emerged, which shows that the cross-regulation between long non-coding RNAs and small non-coding RNAs contribute to phenotypic diversity of glioblastoma subclasses. In this paper, we review data of long non-coding RNA expression, which was evaluated in human glioma tissue samples during a five-year period. Thus, this review summarizes the following: (I) the role of non-coding RNAs in glioblastoma pathogenesis, (II) the potential application of non-coding RNA species in glioma-grading, (III) crosstalk between lncRNAs and miRNAs (IV) future perspectives of non-coding RNAs as biomarkers for glioma.
ISSN: 2072-6694
Appears in Collections:Moksliniai straipsniai / Research articles

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