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Title: The First Application of Nanoelectrochemotherapy in Feline Oral Malignant Melanoma Treatment—Case Study
Authors: Tunikowska, Joanna
Antończyk, Agnieszka
Rembiałkowska, Nina
Jóźwiak, Łukasz
Novickij, Vitalij
Kulbacka, Julita
Keywords: feline melanoma
electrochemotherapy
nanosecond pulsed electric field
CO2 laser
Issue Date: 2020
Publisher: MDPI
Citation: Tunikowska, J.; Antończyk, A.; Rembiałkowska, N.; Jóźwiak, Ł.; Novickij, V.; Kulbacka, J. The First Application of Nanoelectrochemotherapy in Feline Oral Malignant Melanoma Treatment—Case Study. Animals 2020, 10, 556.
Series/Report no.: 10;4
Abstract: The aim of this study was to present the first domestic animal trial of nanosecond electroporation with chemotherapy and CO2 laser surgery. Methods: sixteen-year-old domestic cat with diagnosed melanoma on oral cavity was the case used in the study. Firstly, CO2 laser surgery was used for the removal of most of tumor mass. Then nanoelectrochemotherapy with bleomycin was applied including appropriate margin of healthy tissue. A 15 ± 4 kV/cm × 15 ns pulsing protocol was employed with a total of 800 ± 100 pulses. Only one session of nanoelectrochemotherapy (nanoECT) was performed. Results and conclusions: during the next two weeks areas of focal necrosis were replaced by the granulation tissue. Complete wound healing was observed four weeks after initial treatment. After 15 weeks post treatment, no local recurrence was apparent.
Description: This article belongs to the Special Issue Spontaneous Neoplasms in Animals
URI: http://dspace.vgtu.lt/handle/1/3988
ISSN: 2076-2615
Appears in Collections:Moksliniai straipsniai / Research articles

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