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Title: | Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art |
Authors: | Butkus, Paulius Murauskas, Arūnas Tolvaišienė, Sonata Novickij, Vitalij |
Keywords: | electroporation electroporators nanosecond pulsed electric fields nsPEF pulsed power devices high frequency MOSFET capacitor discharge Blumlein high-voltage generators |
Issue Date: | 2020 |
Publisher: | MDPI |
Citation: | Butkus, P.; Murauskas, A.; Tolvaišienė, S.; Novickij, V. Concepts and Capabilities of In-House Built Nanosecond Pulsed Electric Field (nsPEF) Generators for Electroporation: State of Art. Appl. Sci. 2020, 10, 4244. |
Series/Report no.: | 10;12 |
Abstract: | Electroporation is a pulsed electric field triggered phenomenon of cell permeabilization, which is extensively used in biomedical and biotechnological context. There is a growing scientific demand for high-voltage and/or high-frequency pulse generators for electropermeabilization of cells (electroporators). In the scope of this article we have reviewed the basic topologies of nanosecond pulsed electric field (nsPEF) generators for electroporation and the parametric capabilities of various in-house built devices, which were introduced in the last two decades. Classification of more than 60 various nsPEF generators was performed and pulse forming characteristics (pulse shape, voltage, duration and repetition frequency) were listed and compared. Lastly, the trends in the development of the electroporation technology were discussed. |
Description: | This article belongs to the Special Issue Electroporation Systems and Applications |
URI: | http://dspace.vgtu.lt/handle/1/4012 |
ISSN: | 2076-3417 |
Appears in Collections: | Moksliniai straipsniai / Research articles
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