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Title: Electrochemotherapy Using Doxorubicin and Nanosecond Electric Field Pulses: A Pilot in Vivo Study
Authors: Novickij, Vitalij
Malyško, Veronika
Želvys, Augustinas
Balevičiūtė, Austėja
Zinkevičienė, Auksė
Novickij, Jurij
Girkontaitė, Irutė
Keywords: electrochemotherapy
electroporation
drugs
tumors
Issue Date: 2020
Publisher: MDPI
Citation: Novickij, V.; Malyško, V.; Želvys, A.; Balevičiūtė, A.; Zinkevičienė, A.; Novickij, J.; Girkontaitė, I. Electrochemotherapy Using Doxorubicin and Nanosecond Electric Field Pulses: A Pilot in Vivo Study. Molecules 2020, 25, 4601.
Series/Report no.: 25;20
Abstract: Pulsed electric field (PEF) is frequently used for intertumoral drug delivery resulting in a well-known anticancer treatment—electrochemotherapy. However, electrochemotherapy is associated with microsecond range of electrical pulses, while nanosecond range electrochemotherapy is almost non-existent. In this work, we analyzed the feasibility of nanosecond range pulse bursts for successful doxorubicin-based electrochemotherapy in vivo. The conventional microsecond (1.4 kV/cm × 100 µs × 8) procedure was compared to the nanosecond (3.5 kV/cm × 800 ns × 250) non-thermal PEF-based treatment. As a model, Sp2/0 tumors were developed. Additionally, basic current and voltage measurements were performed to detect the characteristic conductivity-dependent patterns and to serve as an indicator of successful tumor permeabilization both in the nano and microsecond pulse range. It was shown that nano-electrochemotherapy can be the logical evolution of the currently established European Standard Operating Procedures for Electrochemotherapy (ESOPE) protocols, offering better energy control and equivalent treatment efficacy.
Description: This article belongs to the Special Issue Novel Physical and Chemical Methods for Facilitated Drug Delivery
URI: http://dspace.vgtu.lt/handle/1/4056
ISSN: 1420-3049
Appears in Collections:Moksliniai straipsniai / Research articles

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